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Tests to detect neural tube and other defects using current accepted procedures should be considered a part of routine prenatal care in pregnant women receiving valproate.

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The medication is also prescribed for the prevention of migraines and for the treatment of bipolar disorder's manic phases.

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They also marketed Depakote as a medication, even though their own studies showed no benefit.

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Research is showing that people with different genes respond differently to bipolar medications, in fact lithium made me much worse, and there is new research that supports that apoptosis may increase in people who don't do well on lithium.

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Risks for five of these conditions were 2 to 7 times as high for exposed fetuses, and the risk for the sixth condition, spina bifida, was 12 or 16 times as high, depending on the control group used.

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Doctors have studied large numbers of people to find out how well Depakote and the other medicines that contain valproate control seizures.

The efficacy of DEPAKOTE in reducing the incidence of complex partial seizures (CPS) that occur in isolation or in association with other seizure types was established in two controlled trials.

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